In addition to his long ball, Guerrero hit a three-run double and a single that pushed a runner to the plate.
The two-base hit was the 800th hit of his career.
Guerrero has led by example for six games, producing no less than 19 points.
“I don’t see myself as a leader. It’s just that I take it personally to succeed,” Guerrero said. I try to do good things every day and find ways to help the club win.”
Alejandro Kirk drove in two runs with a double and a single as Toronto (38-44) returned to form after a 16-5 rout the day before.
Isiah Kiner-Falefa added an RBI single among his four hits.
Chris Bassitt (7-6) limited the Yankees to one run and six hits in six innings, striking out eight batters.
A performance all the more remarkable as he received an arrow in the forearm from the stick of Aaron Judge in the first round.
“I knew right away that I was good to continue,” said Bassit, whose record is 4-0 since May 22, in eight outings.
Brendon Little, Zach Pop, and Jose Cuas, in his Blue Jays debut, came in relief.
For the Yankees, Austin Wells hit a two-run homer and Judge drove in a run with a single.
Nestor Cortes (4-7) pitched four and a third innings, allowing three runs and seven hits.
In the first inning, Kiner-Falefa’s hit eluded Anthony Volpe’s diving catch for a one-out single. The next batter, Guerrero hit a changeup 403 feet for his 13th homer this year.
A five-run spurt in the sixth helped the Blue Jays pull away.
The game attracted 37,448 spectators to the Rogers Centre.
On the Toronto side, reliever Tim Mayza was designated for assignment and stopper Jordan Romano, of Markham, was sidelined with elbow discomfort.
Mayza was sent to the Buffalo Bisons (AAA), while right-hander Cuas was recalled to take his place.
