When it comes to allergies, not everyone is created equal. Some people suffer from hay fever four months of the year or swell up like balloons at the slightest insect bite, while others never experience these unpleasant symptoms. But why? In a new study, the results of which were published on September 4 in the journal Nature, Researchers have identified the pathway by which immune and nerve cells interact to cause these differences. Ultimately, their findings could pave the way for a new therapeutic approach to treating allergies. Previously, the lead author of this paper, Dr. Caroline Sokol, and her team had shown that the sensory nervous system in the skin, particularly the neurons involved in itch, directly detect allergens. This is thanks to protease activity. This is an enzymatic process shared by many allergens. From this, the researchers hypothesized that innate immune cells could establish a “threshold” in sensory neurons for allergen reactivity and that the activity of the cells could help identify which people are at greatest risk of developing allergies.
A signaling pathway stimulating the production of certain molecules
Here, scientists have carried out different (…)
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