THE ESSENTIAL
- Scientists have discovered that perhexiline, a drug used in cardiology, could work against pancreatic cancer.
- Combined with chemotherapy, this treatment eliminates the tumor.
- This discovery gives hope for a new therapeutic approach to treat one of the most aggressive cancers.
Researchers recently made a promising discovery in the fight against pancreatic cancer. According to work published in the journal iSciencepreclinical trials have shown encouraging results from the use of perhexiline, a drug currently used in Australia and New Zealand to treat a specific cardiac condition.
Impressive results in preclinical trials
Scientists conducted experiments on xenografted mice and found that combining perhexiline with chemotherapy led to complete elimination of the tumor causing pancreatic cancer.
Perhexiline and chemotherapy in synergy
Researchers have found that perhexiline and chemotherapy work synergistically to produce an anti-tumor effect. They believe that this combination induces energetic and oxidative stress within the tumor, leading to its complete destruction. However, the exact mechanisms of this beneficial action still need to be clarified by further research.
-The results of preclinical trials using perhexiline to treat pancreatic cancer are encouraging and offer new possibilities in the fight against this difficult-to-treat disease. This discovery also raises hopes of improving the survival rate and quality of life of patients suffering from pancreatic cancer.
Pancreatic cancer: difficult treatment
Pancreatic cancer is one of the most aggressive and difficult cancers to treat. The diagnosis is often made at an advanced stage, which considerably limits therapeutic options. Usual treatments, such as chemotherapy, have limited effectiveness, making the discovery of new therapeutic approaches all the more crucial.
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