New Southampton manager Ivan Juric has made two changes for his first game in charge.
Joe Aribo and Tyler Dibling have been dropped to the bench following Sunday’s 0-0 draw at Fulham, with Lesley Ugochukwu and Paul Onuachu coming in.
Southampton starting XI: Aaron Ramsdale, Taylor Harwood-Bellis, Jan Bednarek, Nathan Wood, Yukinari Sugawara, Flynn Downes, Lesley Ugochukwu, Kyle Walker-Peters, Matthew Fernandes, Adam Armstrong, Paul Onuachu.
Subs: Ryan Manning, Joe Aribo, Adam Lallana, James Bree, Cameron Archer, Kamaldeen Sulemana, Ryan Fraser, Tyler Dibling, Alex McCarthy.
West Ham have also made two changes, with Konstantinos Mavropanos able to remain in defence after coming off early in Saturday’s 1-1 draw at home to Brighton.
Edson Alvarez has been dropped to the bench while Lucas Paqueta is suspended, so Carlos Soler is back from a ban while Guido Rodríguez has also come in.
West Ham starting XI: Lukasz Fabianski, Aaron Wan-Bissaka, Konstantinos Mavropanos, Max Kilman, Emerson, Guido Rodriguez, Jarrod Bowen, Carlos Soler, Tomas Soucek, Mohammed Kudus, Niclas Fullkrug.
Subs: Aaron Cresswell, Vladimir Coufal, Crysencio Summerville, Luis Guilherme, Danny Ings, Edson Alvarez, Jean-Clair Todibo, Andy Irving, Alphonse Areola.