The deaths were recorded between November 10 and 25 in the Panzi health zone, in Kwango province.
Symptoms included fever, headache, cough and anemia, provincial Health Minister Apollinaire Yumba told reporters at the weekend.
Provincial Deputy Governor Rémy Saki told The Associated Press on Tuesday that between 67 and 143 people had died.
A team of epidemiological experts must visit the region to take samples and identify the problem, according to the vice-governor.
Mr. Yumba advised the population to exercise caution and refrain from touching the dead to avoid contamination. He called on national and international partners to send medical equipment to deal with the health crisis.
Congo is already in the grip of a mpox epidemic, with more than 47,000 suspected cases and more than 1,000 deaths believed to be linked to the disease in the central African country, according to the World Health Organization.
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