Recently, a molecule with powerful potential has shown promising results in the treatment of severe depression. Can it revolutionize the treatment of this condition?
Tl;dr
- Ketamine is being studied as an innovative antidepressant.
- Specifically effective for cases of resistant and urgent depression.
- Several recent works have shown promising results.
- Challenges remain, including side effects and the risk of abuse.
The potential of ketamine as a therapeutic avenue
Originally used as an anesthetic, ketamine has aroused great interest within the medical world for around twenty years. It stands out as a potential treatment for “resistant depressions” – those situations where traditional antidepressants do not work – and constitutes a salutary alternative during a suicidal crisis where prompt action is required.
Promising results despite a difficult context
Recent studies, one published in the British Medical Journal and another in Nature Medicineconfirmed the effectiveness of ketamine in these specific cases.
However, this research only involved a little over a hundred volunteers, a sample size which implies the need more investigation.
Heavy side effects to manage
Despite its potential, caution remains in order. The dangers of ketamine lie in its serious side effects, notably the risk of addiction, and the possible appearance of dissociative personality disorders.
Even more so with the deterioration of its reputation due to its use as a recreational drug, illustrated by the tragic death of American actor Matthew Perry.
Towards a more secure solution
In this context, a study cited in Nature Medicine is testing a new way to administer ketamine: a sustained-release tablet. This alternative, which is less dangerous than the nasal sprays or intravenous injections currently approved, is generating great hopes. As the lead author of this study, Paul Glue, pointed out, patients who tested these tablets reported few side effects.
