Coach Antonio Conte will have to do without Khvicha Kvaratskhelia and Matteo Politano as his Napoli side can temporarily extend their lead at the top of Serie A with a win at Fiorentina.
Kick-off will be at 6:00 p.m. CET (5:00 p.m. GMT) at the Stadio Artemio Franchi, Florence.
The Georgian ace and Italian attacking winger are both ruled out due to injuries, meaning Conte will field an unprecedented attacking trio with Leonardo Spinazzola and David Neres supporting center forward Romelu Lukaku.
With Alessandro Buongiorno also still out, Juan Jesus will team up with Rrahmani in central defense, with Giovanni Di Lorenzo and Matias Olivera on the flanks.
At least the coach will be able to rely on his recurring midfield trio, with playmaker Stanislav Lobotka alongside Zambo Anguissa and Scott McTominay.
Raffaele Palladino’s main doubt for Fiorentina concerns Albert Gudmundsson, who should still be chosen over Lucas Beltran to play behind Moise Kean.
After equalizing late at Juventus, Riccardo Sottil should be confirmed among the starters.
Fiorentina vs Napoli – where to watch on TV
The match at Stadio Artemio Franchi will be available live on TNT Sports 2 and via OneFootball. US fans will be able to watch and stream the match live online via Fubo, Paramount+, DirecTV Stream, CBS Sports Golazo Network and Amazon Prime Video.
Fiorentina vs Naples – compositions probables
Fiorentine (4-2-3-1): De Gea; Dodò, Comuzzo, Ranieri, Gosens; Adli, Mandragore ; Colpani, Gudmundsson, Sottil; Kean.
Naples (4-3-3): Meret; Di Lorenzo, Rrahmani, Juan Jésus, Olivera; Anguissa, Lobotka, McTominay; Nérès, Lukaku, Spinazzola.