Paulo Fonseca sends Rafael Leao and Tammy Abraham to the Milan bench against Lorenzo Lucca’s impressive Udinese.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from this game and Juventus-Lazio on the Liveblog.
The Rossoneri are still reeling after the controversial 2-1 defeat to Fiorentina, which saw both Theo Hernandez and Abraham penalties parried by David De Gea.
The problem arose when Fonseca confessed neither of them were supposed to be taking those spot-kicks, robbing Christian Pulisic of the duties.
Theo Hernandez was sent off and is therefore starting a two-match ban, but Abraham and misfiring Rafael Leao are both sent to the Milan bench in favour of Noah Okafor and Samuel Chukwueze, moving Pulisic to trequartista and Alvaro Morata in a more advanced role.
Davide Calabria, Ismael Bennacer, Alessandro Florenzi and Marco Sportiello are injured, with Matteo Gabbia not at 100 per cent, so Filippo Terracciano starts at left-back.
Udinese have had a sensational start to the season under new coach Kosta Runjaic and were even the Serie A leaders in Week 4.
They won four games this term, drawing at Bologna and losing to Roma and Inter.
Florian Thauvin’s injury has been a blow and he is on the treatment table with Alexis Sanchez, Thomas Kristensen and Gerard Deulofeu.
Lucca leads the attack after his senior Italy debut in the Nations League.
Milan vs. Udinese line-ups
Milan: Cousins; Emerson Royal, Thiaw, Pavlovic, Terracciano; Fofana, Reijnders; Chukwueze, Pulisic, Okafor; Morata
Udinese: Okoye; Kabasele, Bijol, Touré; Ehizibue, Lovric, Karlstrom, Zarraga, Zemura; Iker Bravo, Lucca
