The researchers of the Karolinska Institute in Sweden, the University of Bristol and Imperial College London in the United Kingdom have highlighted an intriguing correlation. Their work suggests that a high plasma caffeine concentration would be associated with a decrease in body mass index (BMI) and the total body fat.
This discovery is based on an in-depth genetic analysis, involving nearly 10,000 participants. The study focused on genetic variations linked to caffeine metabolism, including the CYP1A2 and AHR genes. These variations influence the speed at which our body breaks down caffeine, thus affecting how long it remains in the blood.
Here's a look at the potential effects of caffeine on the body:
- Increased thermogenesis (heat production)
- Stimulation of fat oxidation
- Acceleration of overall metabolism
Caffeine and diabetes risk: a complex relationship
The study also reveals a link between caffeine levels in the blood and the risk of developing type 2 diabetes. Researchers estimate that approximately half the effect of caffeine on diabetes risk would be attributable to the reduction in BMI.
This discovery opens new perspectives for the prevention of diabetes. Calorie-free caffeinated beverages could potentially be explored as a means to aid in body fat reduction. However, it is important to emphasize that the relationship between caffeine and health is not only positive.
| Potential Effects of Caffeine | Impact on health |
|---|---|
| BMI reduction | Positive |
| Reduced risk of diabetes | Positive |
| Cardiovascular effects | Mixed |
Methodology and future implications
The research team used an approach called Mendelian randomization to establish probable causal relationships between genetic variations, diseases such as diabetes, body mass and lifestyle factors. This method, while powerful, is not foolproof and other factors could come into play.
It is important to note that the study did not reveal a significant link between the caffeine levels in the blood and the cardiovascular diseases such as atrial fibrillation, heart failure or stroke.
The researchers emphasize the need for additional studies to confirm the cause-and-effect relationship and determine the optimal amount of caffeine to achieve these potential benefits. As the study authors explain: “Given the extensive consumption of caffeine worldwide, even its small metabolic effects could have important health implications.”
Towards a new perception of caffeine
This study, published in BMJ Medicine in March 2023, is part of an increasingly large body of research on the effects of caffeine on health. It provides important details on the potential mechanisms by which caffeine could influence body composition and the risk of diabetes.
But, it is fundamental to keep in mind that caffeine consumption must be moderate and adapted to each individual. The effects of caffeine can vary greatly from person to person, depending on genetic, environmental, and lifestyle factors.
In the future, these findings could influence public health recommendations and pave the way for new diabetes prevention and weight management strategies. However, it is essential to await additional research before drawing definitive conclusions on the role of caffeine in metabolic health.
study : BMJ Medicine
