The Light Blues are looking to build on a positive start to the competition, following an impressive 2-0 victory over Malmo in Sweden.
It’s Rangers’ first home game of the restructured tournament, and they match up against a Lyon side sitting 11th in Ligue 1, following a difficult opening six games.
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Pierre Sage’s side defeated Olympiakos 2-0 at the Groupama Stadium in their first European tie, and boast the likes of Alexandre Lacazette, Nemanja Matic and Rayan Cherki among their ranks.
The French side come off the back of their first league victory of the season, having defeated Toulouse 2-1 thanks to an injury time winner from Malick Fofana.
Meanwhile, Rangers will look to make it five wins on the bounce after a narrow 1-0 Premiership victory over Hibernian.
RANGERS XI: Butland, Tavernier, Souttar, Propper, Jefte, Diomande, Barron, Cerny, Lawrence, Bajrami, Dessers.
Subs: Kelly, Dowell, Sterling, Kasanwirjo, Balogun, Igamane, King, Raskin, McCausland, Fraser, McKinnon, Lovelace.
LYON XI: Perri, Tagliafico, Veretout, Tolisso, Lacazette, Fofana, Cherki, Mata, Matic, Caleta-Car, Maitland-Niles.
Subs: Bengui-Joao, Descamps, Caqueret, Orban, Zaha, Abner Vinicius, Benrahma, Naikhate, Kumbedia, Diawara, Nuamah, Mikautadze.
