A first in France. A patient followed by the human immunodeficiency information and care center (CISIH) at Sainte-Marguerite hospital in Marseille could represent the first case in France (the eighth in the world) of functional recovery of HIV after an allogeneic bone marrow transplant, the AP-HM announced this Friday.
This is a patient aged around sixty years old, diagnosed with HIV in 1999.Despite effective antiretroviral treatments from 2010, she developed acute myeloid leukemia in 2020. An allogeneic bone marrow transplant carried out at the Paoli-Calmettes Institute in July 2020 made it possible to treat his leukemia. The donor had a rare genetic mutation (Delta 32) in the CCR5 gene, preventing HIV from entering cells“, details the press release.
To date, 7 other cases worldwide
To date, only seven cases of functional cure of HIV after allogeneic bone marrow transplantation, aimed at treating lymphoma or leukemia, have been reported worldwide.
After the transplant, the patient continued her antiretroviral treatment for three years before stopping in October 2023.She continued to be followed very regularly by her doctor at CISIH, Dr Olivia Zaegel-Faucher. More in-depth virological examinations were carried out during its surveillance, in collaboration with the Timone Virology Laboratory of Professor Philippe Colson: in particular ultrasensitive viral load tests, viral culture tests as well as a search for Pro-viral DNA corresponding to the possible reservoir of virus still present in its body, details the AP-HM. All these tests were negative“.
-Prospects for research
The results of this case were presented at international congresses in Munich and Glasgow in 2024.”This advance, although not generalizable to all patients affected by HIV due to the cumbersome treatments associated with allograft, opens new perspectives for research on the virus.“.
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