Southampton manager Russell Martin makes four changes from the team narrowly defeated by Aston Villa last Saturday.
Goalkeeper Alex McCarthy returns from injury, as does Jan Bednarek with Joe Aribo and Kamaldeen Sulemana also given an opportunity from the start.
Southampton XI: McCarthy, Walker-Peters, Manning,
Harwood-Bellis, Bednarek, Sulemana, Downes, Aribo, Fernandes, Armstrong,
Dibling.
Subs: Lumley, Bree, Wood, Sugawara, Amo-Ameyaw, Fraser, Lallana, Onuachu, Archer.
Tottenham boss Ange Postecoglou also rings the changes from the side that drew 1-1 at Rangers on Thursday in the Europa League.
In come Dejan Kulusevski, Lucas Bergvall, Djed Spence, Pape Sarr and Dominic Solanke. Germany forward Timo Werner, who was publicly criticised by his manager for his performance in the Europa League, is on a young-looking bench for Spurs.
Tottenham XI: Forster, Gray, Dragusin, Spence, Udogie, Bergvall, Sarr, Maddison, Son, Kulusevski, Solanke.
Subs: Austin, Porro, Lankshear, Dorrington, Olusesi, King, Hardy, Werner,
Johnson.
