Lazio will aim to maintain their perfect Europa League record against Samu Omorodion’s FC Porto as Taty Castellanos, Pedro and Mattia Zaccagni start.
It kicks off at the Stadio Olimpico at 20.00 GMT.
You can follow all the build-up and action as it happens from this game, Union Saint-Gilloise-Roma and APOEL-Fiorentina on the Liveblog.
The Biancocelesti are top of the big Europa League table after winning all three games, but this might be their toughest test yet.
Squad rotation is kept to a minimum, as Castellanos leads the attack with support from Pedro, Zaccagni and Matteo Guendouzi.
Tijjani Noslin is suspended, with Gaetano Castrovilli ineligible for this competition.
Porto lost the opener 3-2 at Bodo/Glimt, then held Manchester United 3-3 at Old Trafford before a 2-0 victory over TSG Hoffenheim.
The star striker is Atletico Madrid-owned Samu Omorodion, who has 11 goals in 11 games this season, including four in just three Europa League appearances.
Marko Grujic and Ivan Marcano are long-term injury absentees, with Wendell and Ivan Jaime not making the trip either.
Former Juventus defender Tiago Djalò and ex-Udinese man Nehuen Perez both feature, along with winger Galeno.
Lazio vs. Porto line-ups
Lazio: Mandas; Marusic, Gigot, Romagnoli, Nuno Tavares; Vecino, Guendouzi; Tchaouna, Pedro, Zaccagni; Castellanos
Porto: Diogo Costa; Martim Fernandes, Djalò, Neuhen Perez, Francisco Moura; VARELA, Eustaquio; NAMASO, Fabio Vieira, Galeno; Samu Omorodion
Ref: Kabakov (BUL)
