Milan leave Rafael Leao on the bench for the third game running, but Christian Pulisic, Theo Hernandez and Tijjani Reijnders return against Daniel Maldini’s Monza.
It kicks off at the U-Power Stadium at 19.45 GMT.
You can follow all the build-up and action as it happens from this game and Udinese-Juventus on the Liveblog.
The Rossoneri saw their crisis intensify with two defeats in the last three Serie A matches, falling to Fiorentina and Napoli.
Coach Paulo Fonseca resists criticism to again drop star man Leao to the bench in favour of Noah Okafor and Samuel Chukwueze, moving Pulisic – who recovered from flu symptoms – into a trequartista role.
Theo Hernandez and Reijnders were suspended against Napoli, but are available again here, with Matteo Gabbia, Luka Jovic, Ismael Bennacer and Alessandro Florenzi injured.
Filippo Terracciano gets a rare start to rest Emerson Royal, with Fikayo Tomori dropped again.
Monza have only one victory all season, 3-0 away to Verona, but did hold Roma and Inter to draws here.
Coach Alessandro Nesta is coming off a midweek 2-0 defeat to Atalanta, missing Stefano Sensi, Samuele Birindelli, Andrea Petagna and Alessio Cragno.
Daniel Maldini, son of former Milan director Paolo and a product of the Rossoneri youth academy, has shaken off a shoulder injury, while Warren Bondo returns from suspension.
Matteo Pessina is only fit for the bench after a knock.
Monza vs. Milan line-ups
Monza: Turati; Izzo, Marì, Carboni; Pereira, Bianco, Bondo, Kyriakopoulos; Maldini, Mota; Djuric
Milan: Cousins; Terracciano, Thiaw, Pavlovic, Theo Hernandez; Fofana, Reijnders; Chukwueze, Pulisic, Okafor; Morata
