Published in the journal Cella study describes for the first time the closely linked oscillations of the neurotransmitter norepinephrine, brain blood and cerebrospinal fluid that combine during non-REM sleep in mice. If these oscillations are so important, it is because they fuel the glymphatic system, whose function is to eliminate metabolic waste from the brain. Some of this waste is linked to neurodegenerative diseases, such as Alzheimer's disease. “As the brain transitions from wakefulness to sleep, processing of external information decreases while processes such as glymphatic elimination of waste are activated”said Maiken Nedergaard, neuroscientist and co-director of the Center for Translational Neuromedicine at the University of Rochester and lead author of the study.
Warning for people taking Zolpidem
The study issues a warning to people who take Zolpidem, a sleeping pill commonly prescribed for sleep. Although Zolpidem effectively induced sleep in mice, it also suppressed norepinephrine oscillations, disrupting the glymphatic system and hindering the brain's waste removal processes. As a result, the accumulation of these toxic proteins in the brain can cause the appearance of neurological disorders.
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