There are only three survivors from the Newcastle side which held Manchester City to a 1-1 draw at the weekend.
Fabian Schar, Joelinton and Harvey Barnes all keep the places as Magpies boss Eddie Howe opts to rotate his squad.
Martin Dubravka replaces Nick Pope in goal while Sean Longstaff, Tino Livramento, Miguel Almiron and Joe Willock are among those named in the starting line-up.
Newcastle XI: Dubravka, Livramento, Krafth, Schar, Kelly, Joelinton, Willock, Longstaff, Almiron, Osula, Barnes.
Subs: Ruddy, Vlachodimos, A Murphy, Burn, Tonali, Hall, Guimaraes, J Murphy, Gordon.
Image source, BBC Sport
AFC Wimbledon have not played since a goalless draw at Bradford on 21 September and boss Johnnie Jackson makes three changes to his side from that match.
Defender Huseyin Biler, midfielder Callum Maycock and striker Joe Pigott are all recalled to the starting line-up.
Alistair Smith, Matty Stevens and Josh Neufville are the players to miss out and are named among the substitutes.
AFC Wimbledon XI: Goodman, Ogundere, Lewis, Harbottle, Tilley, Hippolyte, Ball, Maycock, Biler, Bugiel, Pigott.
Subs: Furlong, Kelly, Neufville, O’Toole, Sasu, Smith, Stevens, Ward, Williams.
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