The alert is not new, even if it may seem absurd. The National Agency for the Safety of Medicines and Health Products (ANSM) has been warning for several years about the dangers that exist between ingesting certain medications with… fruit. And a common fruit, which many French people like to eat in the morning, for breakfast, for example. It’s about grapefruit, Notre temps reveals. But why could consuming a grapefruit be contraindicated when taking a medication?
The ANSM explains that the fruit contains furanocoumarins. These are phototoxic substances which are naturally contained in certain plants, particularly in citrus peels. And these substances change the absorption of drugs. Thus, several types of treatments against certain pathologies are clearly not recommended: drugs against excess cholesterol (simvastatin), immunosuppressive drugs prescribed after an organ transplant (cyclosporin, tacrolimus, etc.), an anxiolytic (buspirone) or even an antipsychotic, quetiapine.
And the list is still long. The problem is that the problem remains, regardless of the form consumed (fruit, juice, jam, candied peel, etc.). Furanocoumarins are resistant to cooking and neutralize an enzyme that helps eliminate certain medications in the body. As a result, the passage of the latter in the body is amplified, with the risk of increasing undesirable effects. (…)
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