Paulo Dybala and Artem Dovbyk lead the way for Roma as they try to build momentum against tough to beat Genoa.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens on the Liveblog.
The Giallorossi have been revitalised by Claudio Ranieri and are still riding the wave of enthusiasm from the Derby della Capitale victory over rivals Lazio.
However, they needed a last-gasp Dovbyk penalty to secure a 2-2 draw away to Bologna on Sunday.
Bryan Cristante remains the only injury absentee, with Dybala and Dovbyk the front two, with Lorenzo Pellegrini again starting in a supporting role.
Genoa have lost only one of their eight matches since Patrick Vieira took over on November 20 and that was a narrow 2-1 to leaders Napoli.
-That is despite the on-going injury crisis that rules out Milan Badelj, Vitinha, Junior Messias, Mario Balotelli, Caleb Ekuban, Brooke Norton-Cuffy, Ruslan Malinovskyi and Honest Ahanor.
Andrea Pinamonti is the centre-forward and Fabio Miretti has shaken off a knock to start in the 4-3-3 formation, with Alessandro Zanoli completing the trident.
Roma vs. Genoa line-ups
Roma: Svilar; Mancini, Hummels, N’Dicka; Saelemaekers, Koné, Paredes, Angelino; Dybala, Pellegrini; Dovbyk
Genoa: Loyal; De Winter, Bani, Vasquez, Martin; Frendrup, Masini, Thorsby; Zanoli, Pinamonti, Miretti
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