Milan bring Alvaro Morata and Rafael Leao back to the starting XI in a must-win match against an Empoli side with injury issues.
It kicks off at San Siro at 17.00 GMT.
You can follow all the build-up and action as it happens from this game, Como-Monza and Bologna-Venezia on the Liveblog.
The Rossoneri are fresh off a Champions League victory against Slovan Bratislava, although the 3-2 result was more complicated than they perhaps needed it to be.
Morata was suspended for that game and Leao came off the bench to score, but both are back in the starting XI here.
Luka Jovic, Ismael Bennacer and Alessandro Florenzi are long-term injury absentees, while Christian Pulisic has shaken off a knock.
The pressure is on Milan to win here, as they were jeered off the pitch after a dire 0-0 draw with Juventus and are falling behind with back-to-back stalemates in Serie A.
Noah Okafor is suffering from flu symptoms and Yunus Musah again gets a role in the supporting trio.
Empoli are unbeaten in three and sit pretty comfortably mid-table on 16 points, only three behind Milan even though the Rossoneri have a game in hand.
Nicolas Haas underwent surgery for a ruptured anterior cruciate ligament in his knee, joining Mattia De Sciglio, Alberto Grassi, Saba Sazonov, Jacopo Fazzini, Tyronne Ebuehi and Szymon Zurkowski on the treatment table.
Former Milan players in the squad include Lorenzo Colombo and goalkeeper Devis Vasquez, but they have to reshuffle the midfield.
Milan vs. Empoli line-ups
Milan: Maignan; Emerson Royal, Gabbia, Thiaw, Theo Hernandez; Fofana, Reijnders; Musah, Pulisic, Leao; Morata
Empoli: Vasquez; Goglichidze, Ismajli, Viti; Gas, Henderson, Anjorin, Pezzella; Colombo, Maleh; Pellegri
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