Tariq Lamptey is fit to start for Brighton for the first time since October, while Lewis Dunk is also back on the bench after an injury-enforced absence.
Carlos Baleba is suspended with Matt O’Riley replacing him in midfield, while Joel Veltman misses out on the matchday squad.
Brighton XI: Verbruggen; Lamptey, Igor, van Hecke, Estupinan; Ayari, O'Riley; Rutter, Pedro, Mitoma; Welbeck
Subs: Steele, Dunk, Enciso, Adingra, Minteh, Wieffer, Ferguson, McConville, Slater
Southampton hand a Premier League debut to 29-year-old goalkeeper Joe Lumley, with Alex McCarthy dropped after conceding three against Liverpool.
There are four changes in total for Southampton, with Ryan Fraser also benched while Adam Lallana and Paul Onouachu picked up injuries last Sunday.
Yukinari Sugawara, Cameron Archer and Ryan Manning come into the XI.
Southampton XI: Lumley; Sugawara, Stephens, Harwood-Bellis, Walker-Peters; Dibling, Downes, Fernandes, Manning; Archer, Armstrong
Subs: McCarthy, Aribo, Edwards, Bree, Wood, Brereton Diaz, Sulemana, Fraser, Amo-Ameyaw