The midfield will be anchored by Argentinian defensive midfielder Guido Rodríguez, Lucas Paquetá and Álvarez, who is making his first Premier League start since being withdrawn at half-time against Chelsea on 5 May.
Captain Bowen, fresh from scoring his second goal of the season in the Carabao Cup second round win over Bournemouth, is joined in attack by Mohammed Kudus, who netted a stunning acrobatic effort at Etihad Stadium in the last meeting between the sides, while Michail Antonio again leads the line.
Lopetegui can call upon an exciting combination of youth and experience from the bench against Pep Guardiola’s side, with Academy defender Kaelan Casey and hugely promising talent Luis Guilherme named among the substitutes.
The manager could also turn to goalkeeper Fabiański; defenders Vladimír Coufal and Jean-Clair Todibo; central midfielders Andy Irving and Tomas Souček; and attackers Crysencio Summerville and Niclas Füllkrug.
Aaron Cresswell is absent as he recovers from a hamstring issue, while Carlos Soler is not available for this evening’s game after completing a season-long loan move from Paris Saint-Germain late on deadline day.
West Ham United: Areola, Wan-Bissaka, Mavropanos, Kilman, Emerson, Rodriguez, Alvarez, Paqueta, Bowen ©, Kudus, Antonio
Subs: Fabiański (GK), Casey, Todibo, Coufal, Souček, Irving, Guilherme, Summerville, Füllkrug
Manchester City: Ederson, Lewis, Akanji, Dias, Gvardiol, Kovacic, Silva, Grealish, De Bruyne ©, Doku, Haaland
Subs: Ortega (GK), Walker, Stones, Aké, Rodri, Gündogan, Nunes, O’Reilly, McAtee
Referee: Michael Oliver
