Credit: Pasteur Institute – François Gardy
INTERVIEW – After a bone marrow transplant received 3 years ago in Geneva, a patient no longer has traces of HIV in his body. A very special case which represents a major advance in AIDS research.
Professor Asier Sáez-Cirión, head of the Viral Reservoirs and Immune Control Unit at the Pasteur Institute, discusses the exceptional case of the patient from Geneva, in remission from HIV after a bone marrow transplant.
LE FIGARO. – The Geneva patient is one of the rare cases of HIV remission without reappearance of the virus after stopping treatment. Can you explain his case to us?
Pr Asier SAEZ-CIRION. , After a bone marrow transplant, with the agreement of the medical team and Romuald (the patient from Geneva), we stopped the antiretroviral treatments. And the big news is that the donor for the marrow transplant did not carry the CCR5-delta 32 mutation, unlike other comparable transplants carried out on patients carrying HIV. This rare genetic mutation makes cells naturally resistant to HIV. However, despite this absence of mutation, the virus has not reappeared, and we can now say that the patient is probably cured…
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