CAR-T cells, researchers against cancer: episode /3 of the New Therapies podcast

T lymphocytes play an essential role in immunity, in the detection and destruction of intruders such as viruses or cancer cells. This is the concept that CAR-T cells are based on. These are T lymphocytes enhanced and reprogrammed to express a chimeric receptor capable of specifically recognizing tumor cells.

Cells programmed to kill

CAR-T cells have shown impressive results in hematological cancers, with a clinical response rate of 80%. But everything is not yet perfect. What is the recipe for this cell therapy? How to limit relapses? And will we one day be able to reduce their price? Answers with Laurie Menger, INSERM researcher at the Gustave-Roussy Institute in Villejuif.

Additional documentation: a popularized article from Inserm with other resources ( Without Mario, what are CAR-Ts?, 2019), an explanation of the manufacturing recipe and the link where the image comes from ( CAR-T cells – Gustave Roussy)