Ahead of Fabiański, Wan-Bissaka and Vladimír Coufal start at right-back and left-back respectively, either side of Maximilian Kilman and Todibo in central defence.
In midfield, Mexico international Álvarez makes his first start of the season, after recovering from a hamstring injury to feature from the substitutes’ bench against Palace at the weekend
Álvarez is partnered in the middle by James Ward-Prowse, who also makes his first start of the 2024/25 campaign after an impressive debut campaign in Claret and Blue.
Captain Jarrod Bowen could start on the right, as he did against Palace, with Tomáš Souček filling the No10 position and Summerville on the left wing.
Füllkrug, who scored 16 goals for Borussia Dortmund last season, including scoring the decisive goal in BVB’s 1-0 semi-final first leg win against Paris St-Germain, looks for his first in Hammers colours as he leads the line in east London.
A strong bench is named too by Lopetegui, with seasoned internationals Lucas Paquetá, Mohammed Kudus, Michail Antonio, Emerson, Guido Rodríguez and Dinos Mavropanos to call upon. Wes Foderingham, Andy Irving and Luis Guilherme complete the matchday squad.
West Ham United: Fabiański, Wan-Bissaka, Todibo, Kilman, Coufal, Álvarez, Ward-Prowse, Soucek, Bowen ©, Summerville, Füllkrug
Subs: Foderingham (GK), Emerson, Mavropanos, Irving, Paqueta, Rodriguez, Guilherme, Kudus, Antonio
AFC Bournemouth: Neto ©, Smith, Huijsen, Senesi, Hill, Ouattara, Scott, Christie, Tavernier, Sinisterra, Jebbison
Subs: Travers (GK), Kerkez, Dennis, Cook, Zabarnyi, Araujo, Kluivert, Semenyo, Evanilson
Referee: Peter Bankes