UROBIOME: Analyze it to predict kidney stones

Indeed, bacteria such as E. coli and Lactobacillus normally found at low levels in urine, which come from bacterial communities that reside in the kidneys, can promote or prevent the formation of kidney stones. Here, the researchers provide definitive proof of the influence of the urobiome (microbiome of different organs of the urinary tract, including the bladder and kidneys) on kidney health and the formation of kidney stones.

The urinary tract is not sterile and low levels of bacteria are normal

The study identifies and characterizes this “weak” bacterial community by combining preclinical, human and laboratory studies. This work identifies specific bacteria in the microbiome that can promote or block the development of kidney stones. They also show that excessive use of antibiotics adversely modifies the renal microbiome, inducing the emergence of bacteria favoring stones.

Taken together, these observations suggest that the kidney microbiome influences the formation of kidney stones and that it could probably also influence the development of other diseases.

“Urological diseases such as kidney stones affect 63% of the adult population and are on the rise. Our work points towards bacteria. We must therefore go beyond the hypothesis of sterility to develop new treatments and new, more effective preventive options.”