An HIV-positive patient since 1999, followed by the Public Assistance of Marseille hospitals, could be the first potentially cured HIV patient in France, and the eighth in the world after an allogeneic bone marrow transplant.
The news is a real message of hope for all people affected by HIV in France and around the world. In a press release, the Marseille Hospitals Public Assistance announces that a sixty-year-old diagnosed with HIV in 1999 and followed by the human immunodeficiency information and care center at Sainte-Marguerite hospital in Marseille “could represent the first case in France and the eighth in the world of functional cure for HIV after allogeneic bone marrow transplantation.
Despite effective antiretroviral treatments from 2010, the patient developed leukemia in 2020, requiring this allograft at the Paoli-Calmettes Institute. “The donor had a rare genetic mutation (Delta 32) in the CCR5 gene, preventing HIV from entering cells”writes the AP-HM.
Negative test
“To date, only seven cases of functional cure of HIV after allogeneic bone marrow transplantation, aimed at treating lymphoma or leukemia, have been reported worldwide. For six of them, the donor carried the Delta 32 mutation on the CCR5 receptor.
-“After the transplant, the patient continued her antiretroviral treatment for three years before stopping in October 2023, and was followed very regularly by her doctor at the CISIH”specifies the AP-HM. More in-depth virological examinations were carried out during its surveillance, in particular to determine the “possible reservoir of virus still present in his body.” However, all of these tests are negative. The results of this case were presented at international conferences in Munich and Glasgow in 2024.
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