The study case-control study carried out with participants aged on average 72 years and 61% men, including 346 patients suffering from Parkinson’s disease matched to 4,813 controls free of the disease, reveals in fact that:
- exposure to fine PM2.5 particles and nitrogen dioxide (NO2) is well associated with statistically significant increases in the risk of Parkinson’s disease, and the associated symptom of dyskinesia;
- this result holds even after taking into account possible confounding factors, including age, sex, ethnic origin, year of exposure assessment and place of residence, urban or rural;
- exposure to pollution in the top quartile is associated with a 36% increased risk of akineto-rigid form of the disease;
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for each increase of 1 μg/m3 of PM2.5, the risk of dyskinesia is increased by 42%;
- no association between the level of exposure to PM2.5 and all-cause mortality is observed in these Parkinson’s patients.
These results confirm the conclusions of previous association studies, but also suggest thatreducing air pollution may help reduce the risk of Parkinson’s diseaseby modifying the phenotype of the disease and in particular the degree of dyskinesia.
The authors Brittany Krzyzanowski, researcher and Dr Rodolfo Savica of the Mayo Clinic therefore confirm the strong correlation between pollution and the risk of developing an akineto-rigid form of Parkinson’s disease.
Health
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