December 1st is World AIDS Day. Adobe Stock
World AIDS Day takes place on December 1, an opportunity to raise public awareness of the challenges of the fight against HIV and AIDS, as well as the scientific progress made against this epidemic. Although significant advances have been made in recent decades, HIV remains a major public health problem: there are an estimated 39.0 million people living with the virus at the end of 2022 (according to the WHO) . To take stock, we have selected for you some recent content published on our platforms which clearly highlights the research carried out within Inserm.
To better understand the virus, but also to know where the research is, do not hesitate to consult the AIDS and HIV file, updated in 2024 and written in collaboration with the ANRS-MIE.
AIDS and HIV, When will there be a cure? : https://www.inserm.fr/dossier/sida-et-vih/
Our other news:
HIV changes cellular targets at late stage of infection
HIV spreads throughout the body by infecting different CD4 T lymphocytes, depending on the stage of infection. An Inserm team has just described the profile of lymphocytes which are infected at the late stage of the disease, when the immunodeficiency is life-threatening for the patient. Targeting the markers that characterize these lymphocytes could facilitate their elimination and slow down viral replication.
Read the news on: https://www.inserm.fr/actualite/le-vih-change-de-cible-cellular-au-stade-avance-de-linfection/
Discovery of rejuvenation of CD8+ T lymphocytes after 20 years of treatment for HIV infection
The goal of eliminating HIV among people living with the virus is to achieve a lasting, treatment-free cure. One of the strategies to eradicate the virus consists of stimulating immune responses, in particular those mediated by CD8+ cytotoxic lymphocytes. A study supported by the ANRS MIE and carried out by teams from Inserm, the University of Bordeaux and the CNRS (ImmunoConcEpT), examined the evolution of CD8+ T lymphocytes after several decades of antiretroviral treatment in people living with HIV. Contrary to what scientists expected, the results show that there is a renewal of CD8+ T cells, suggesting a capacity of the immune system to generate new responses. The results of this work have just been published in the journal Nature Immunology.
Read the press release on: https://presse.inserm.fr/decouverte-dun-rajeunissement-des-lymphocytes-t-cd8-apres-20-ans-de-traitement-de-linfection-par-le-vih /68894/
Listen or re-listen to episode number 2 of the Inserm podcast Les Volontaires, the Inserm podcast with citizens who advance medical research.
“The trans HIV prevention activist” is episode 02 of season 1 of Volunteers, the Inserm podcast with citizens who advance medical research.
What are the vulnerabilities and living conditions in France of transgender people living with HIV? It was to answer this question that Giovanna, a community activist in Paris, turned to Sesstim, an Inserm laboratory in Marseille specializing in human and social sciences. Together, they launched the Trans&VIH study. Its particularity: researchers and HIV-positive trans people collaborated at all stages of the project. In this Inserm podcast, Giovanna confides to Chandrou Koumar, journalist and doctor in neuroscience, about her volunteer journey and her pride in contributing to research useful to all.
The episode is available on Apple Podcast, Audible, Deezer, Spotify, YouTube and wherever you usually listen to your podcasts.
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