How to slow down Alzheimer’s disease? According to a study, drinking coffee would be a promising avenue – Evening edition Ouest-France

How to slow down Alzheimer’s disease? According to a study, drinking coffee would be a promising avenue – Evening edition Ouest-France
How to slow down Alzheimer’s disease? According to a study, drinking coffee would be a promising avenue – Evening edition Ouest-France

By the evening edition, with Agence France-Presse.

Caffeine, a future treatment for Alzheimer’s disease? A new study suggests that its effects could be beneficial in slowing its progression in patients affected at an early stage.

Various epidemiological studies have already highlighted that regular and moderate consumption of caffeine seems to slow down cognitive decline linked to aging and the risk of developing Alzheimer’s disease. In new work, published Friday, July 5, 2024 in the scientific journal “Brain”, researchers, gathered within the French research center Lille Neuroscience and Cognition, analyzed mechanisms underlying the development of the disease. It is characterized by disorders of memory, executive functions and orientation in time and space.

Read also: This promising molecule could reverse the effects of Alzheimer’s disease

Caffeine blocks receptors

Scientists have shown that the pathological increase in receptors in neurons, during the development of the disease in animals, promotes the loss of synapses, which link neurons. A mechanism that leads to the early development of memory disorders. In 2016, the same research team described one of the mechanisms by which caffeine could block these same receptors in animals, the expression of which is abnormally increased in the brains of people with Alzheimer’s disease.

“We can therefore imagine that by blocking these receptors, the activity of which is increased in patients with Alzheimer’s, caffeine could prevent the development of memory disorders and even other cognitive and behavioral symptoms.”said David Blum, research director at Inserm (French Institute of Health and Medical Research), one of the authors of the study.

Read also: This five-word test is one of the simplest to detect the beginnings of Alzheimer’s disease.

A clinical trial in progress

A phase 3 clinical trial, led by the Lille University Hospital, including 248 patients is underway. Half of the patients will receive 400 mg of caffeine, the other half a placebo. Its objective is to evaluate the effect of caffeine on the cognitive functions of patients with early to moderate forms of Alzheimer’s disease.

Read also: This physical change could allow dementia to be detected twelve years before the first symptoms

“If the trial is positive, it will prompt us to start a larger trial. Potentially, it could mean that caffeine can be used as a drug for the treatment of this disease,” says David Blum.

-

-

PREV Sweet skin, aggressiveness, repellents, remedies…: ten things to know about mosquitoes and their bites
NEXT Lung cancer: new hope to prevent relapses