In a context of organ shortage, a surgical innovation is experiencing renewed interest: xenograft, or the transplant of porcine organs into humans. Does this practice have a bright future?
Every year in France, around 1,000 patients die while waiting for a transplant. Faced with this problem, xenotransplantation seems to be a solution. It has been considered since at least the 17th century, but with advances in genome editing over the past two decades, we are entering a new era. Last May, a patient died, two months after a genetically modified pig kidney transplant. The successes are mixed. This technology has not yet left the laboratory but we are getting closer. It has just been integrated into the international BANFF classification. One more step towards the standardization of practices.
How can we better understand transplant rejections, whether from human or animal donors?
A report produced by Alexandre Morales.
At the Institute of Transplantation and Regenerative Medicine in Paris, Fariza Mezine et Erwan Morgand work to look for biological signals indicating transplant rejection on the part of the recipient.
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Publication : Hybrids. Transplanting organs from animals to humans by Catherine Rémy (CNRS Editions, October 2024)
World first: entry of xenotransplantation into the international classification of graft rejections (Paris Cité University)
Not stupid – What is a xenograft? (Inserm, 2024)
Grafting pig skin to treat wounds: a promising avenue (The Conversation)
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Musical references
Today’s headline: My organs par 28 Saphyr
The opening credits: goca world by Altin Gun
The end credits: Pingpxng par Yin Yin
