Sleep disorders, first signs of Charcot’s disease?

The hypothalamus involved in the very beginning of the disease?
“These tests indicate that the two groups of individuals suffered from the same type of sleep disorders: a greater awakening time and a deep amount of sleep lower than data from controls,” write the authors of the study in A press release, published Tuesday, February 4. The results, published in the Journal Science Translational Medicine, suggest that sleep disorders are present and observable, and this early, several years before the manifestation of motor disorders.
Scientists then sought the origin of these sleep disorders in the brain. A track: Orexine neurons, specific hypothalamus neurons known to play a role in stimulating the state of awakening. In mouse models with ALS, in which the same sleep disorders have been observed, the researchers discovered that the neurons circuits where orexin neurons are integrated are altered, by the disappearance of annex neurons during the disease .
A new therapeutic target?
An orexin inhibitory molecule, already prescribed against insomnia, has been administered to sick mice. Results: After a single oral take the sleep of the mice was restored. The activity of annex neurons of orexin neurons was also restored and after 15 days of treatment, a preservation of motor neurons was observed in mice. The team of researchers now want to test the molecule in patients with SLA: can restoring their sleep brake the disease?
“The discoveries of our team are important at two levels. First of all, they highlight a new chronology of SLA symptoms, again questioning the origins of the disease, and in particular the role of the brain in its genesis, explains Luc Dupuis, co-dear author of the study. They also represent a slight hope for the patients, and those who declare the disease, imagining that Idag on the first manifestations of it can slow down its extremely rapid progression. »»
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Source: Health destination